BPC-157—short for Body Protection Compound-157—is a synthetic peptide composed of 15 amino acids. Its sequence corresponds to a fragment of a larger protein identified in human gastric juice. Published research on BPC-157 remains predominantly preclinical, involving animal and cell-culture models rather than established human clinical use.
Research overview
Preclinical studies have examined BPC-157 across several biological research models. These studies explore cellular signaling, blood-vessel formation, fibroblast behavior, and tissue response. Findings from animal or cell models do not establish safety or effectiveness in people.
Areas examined in published research
- Tendon-cell models: studies have examined fibroblast outgrowth, survival, migration, and FAK-paxillin signaling.
- Angiogenesis signaling: animal research has evaluated VEGF-associated blood-vessel formation in muscle and tendon models.
- Growth-factor signaling: laboratory studies have reported changes in growth-hormone-receptor expression in tendon fibroblasts.
- Gastrointestinal models: BPC-157 has also been investigated in preclinical gastric and intestinal research.
The available evidence is overwhelmingly preclinical, with limited controlled human data and substantial reliance on a relatively small group of researchers. BPC-157 is not an established treatment.
Molecular specification
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
|---|---|
| Molecular formula | C62H98N16O22 |
| Molecular weight | 1419.5 g/mol |
| CAS number | 137525-51-0 |
| Available formats | 5 mg and 10–15 mg configurations as listed in the product selector |
Quality and sourcing
Prisim Wellness BPC-157 is produced through a Registered 503B outsourcing facility under documented quality processes. Product batches are tested for identity, purity, and potency, with third-party verification and batch documentation available where applicable.
References
- Krivic A, et al. Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: promoted tendon-to-bone healing. J Orthop Res. 2006;24(5):982–989. PubMed
- Brcic L, et al. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. J Physiol Pharmacol. 2009;60(Suppl 7):191–196. PubMed
- Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing. J Appl Physiol. 2011;110(3):774–780. PubMed
- Chang CH, et al. Pentadecapeptide BPC 157 enhances growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066–19077. PubMed